KRAS and neoplasm: Moreover, the constitutive activation of NRF2 is crucial for tumour survival since many tumours have been found to display high levels of ROS as a result of the activity of oncogenes such as K-Ras, c-Myc and Mesenchimal epithelial transition factor (c-Met), Epidermal Growth Factor Receptor (EGFR), Platelet-derived growth factor receptor (PDGFR) or Src [207,208,209] via NOX activation [210].