Among the upregulated DE miRNAs, the top five GO enrichment terms were catabolic process, protein ubiquitination, cytokinesis, cell cycle, and cellular protein metabolic process (Figure 5D); the top five KEGG pathways were chronic myeloid leukemia, pathways in cancer, FoxO pathway, protein process in endoplasmic reticulum, and neurotrophin pathway (Figure 5E); and the top five reactome pathways were developmental biology, axon guidance, signaling by NGF, signaling by EGFR, and signaling by VEGF (Figure 5F). The gene discussed is EGFR; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.