Among the upregulated DE miRNAs, the top five GO enrichment terms were catabolic process, protein ubiquitination, cytokinesis, cell cycle, and cellular protein metabolic process (Figure 5D); the top five KEGG pathways were chronic myeloid leukemia, pathways in cancer, FoxO pathway, protein process in endoplasmic reticulum, and neurotrophin pathway (Figure 5E); and the top five reactome pathways were developmental biology, axon guidance, signaling by NGF, signaling by EGFR, and signaling by VEGF (Figure 5F). This evidence concerns the gene BDNF and chronic myelogenous leukemia, BCR-ABL1 positive.