AKT1 and cancer: Among the downregulated DE miRNAs, the top five GO enrichment terms were Golgi vesicle transport, protein complex assembly, Ras protein signal transduction, cytokinesis, and intracellular protein transport (Figure 5G); the top five KEGG pathways were metabolic pathways, protein process in endoplasmic reticulum, endocytosis, pathways in cancer, and PI3K–Akt pathway (Figure 5H); and the top five reactome pathways were developmental biology, axon guidance, cell cycle, adaptive immune system and post-translational protein modification (Figure 5I).