The difference between two autoimmune demyelinating diseases of the central nervous system, MS and NMOSD, in their association with GTF2I is supported by our recent studies reporting that the GTF2I rs73366469, another Taq-SNP of the intergenic locus, is associated with NMOSD, but not with MS, myelin oligodendrocyte glycoprotein-associated disorders or anti-N-Methyl-D-Aspartate receptor encephalitis [19,20]. The gene discussed is GTF2I; the disease is myeloid sarcoma.