As for the renal actions, geraniol exhibited protection against cyclosporine A-induced nephrotoxicity via lowering inflammation mediators, including (ICAM-1, IL-18, and NF-κB) [39], protection against methotrexate-induced acute kidney injury via Keap1/Nrf2/HO-1 and MAPK/NF-κB pathways [40]. Here, IL18 is linked to acute kidney injury.