VEGFA and asthma: In a house dust mite (HDM)-induced asthma model, EGCG decreased tissue injury, inflammation, mucus production and collagen deposition, and alleviated HDM-induced M2 macrophage infiltration in the lung, probably via suppressing hypoxia-inducible factor (HIF-1)α/vascular endothelial growth factor (VEGF)A-mediated M2 skewing of macrophages [187].