In fine particulate matter-induced asthma model in rats, EGCG mitigated lung injury and inflammatory cell infiltration, decreased bronchial wall and bronchial smooth muscle thickness, and reduced the expression of HMGB1 and RAGE mRNA and protein, contributing to inflammatory cascade in asthma, while more obvious results were observed for higher doses of EGCG [38]. This evidence concerns the gene AGER and asthma.