Ruart et al. found that damage to sinusoidal endothelial cells during acute liver injury aggravates oxidative stress and activates stellate cells to promote liver fibrosis; furthermore, autophagy-impaired liver sinusoidal endothelial cells (LSEC) can cause ROS accumulation and elevated p62 levels, which activates the upregulation of Nrf2 and its target genes [185]. This evidence concerns the gene NFE2L2 and Hepatic fibrosis.