MEG3 and neoplasm: FSP1 suppresses lipid peroxidation through the reduction of ubiquinone to ubiquinol, which in turn either directly reduces lipid radicals to terminate lipid autoxidation, or indirectly via regenerating vitamin E. In T cell lymphoblastic lymphoma cells, FSP1 was shown to be upregulated by the long non-coding RNA maternally expressed 3 (MEG3), a regulatory RNA involved in tumor development [49].