CYBB and pulmonary emphysema: Importantly, our findings are consistent with Yao et al., who indicated the attenuation of ROS production and exaggerated inflammation and emphysema in NOX2 knockout animals, as discussed earlier [28], although the study by Trocme et al., on the other hand, contradicts these findings showing that NOX2 knockout animals were protected from elastase-induced emphysema [29].