TXN and cancer: In this respect it should be noted that in mammalian cells GPXs are thought to regulate the process of ferroptosis [56] and that we recently reported that suppressing the cluster transfer function of NAF-1 (via the inducible expression of H114C) altered GPX expression, activated ferroptosis, and caused the enhanced accumulation of TXNIP (a major regulator of the mammalian TRX network) in cancer cells [11].