Given the involvement of both SOD1 and DJ-1 in ALS and PD, and considering the purported participation of DJ-1 in the SOD1 maturation pathway, this work aimed to evaluate in vivo, using Drosophila melanogaster as an animal model, whether the antioxidant properties of DJ-1 were dependent on the presence of SOD1. Here, PARK7 is linked to Parkinson disease.