Obesity-associated chronic inflammation of insulin target tissues implies an impairment of glucose and lipid metabolism, a blockage of insulin signaling, and lower insulin sensitivity [9], since accumulation of fatty acids favors the activation of c-Jun N-terminal kinase (JNK) and of inhibitor of κB kinase (IKK) [8]. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.