Recently, it has been shown that the methanolic extract from Centaurea albonitens has a cytotoxicity activity against diverse hematologic malignant cell lines (human pre-B ALL cell lines (NALM-6 and REH), human APL cell line (NB4), human multiple myeloma cell line (KMM-1)), which are associated with the activation of apoptosis and upregulated caspase-3 activity [35]. This evidence concerns the gene CASP3 and acute promyelocytic leukemia.