NFKB1 and hepatocellular carcinoma: Similarly, thymoquinone (TQ), the main active ingredient of Nigella sativa, has been reported to exert potent antiproliferative activities against both hepatocellular carcinoma and medulloblastoma cells in part by inhibiting NF-κB signaling by engaging both intrinsic and extrinsic apoptotic pathways in an ROS-dependent manner [19,28].