The serum of patients with ALS also shows elevated concentrations of oxidative stress markers such as 3-nitrotyrosine (3-NT), 4-HNE, OH8dG and high activity of the antioxidants defenses such as glutathione peroxidase, superoxide dismutase (SOD), glutathione reductase, and malondialdehyde (MDA) [58,59]. This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.