Additional evidence of oxidative stress in MS are the presence of increased protein carbonyls, NO metabolites, SOD, catalase, glutathione reductase, inducible nitric oxide synthase (iNOS), protein carbonyl, 3-NT, isoprostanes, MDA, 8-iso-prostaglandin F2α and products of DNA oxidation in blood, serum, urine and postmortem brain of MS patients [71]. This evidence concerns the gene GSR and myeloid sarcoma.