HMOX1 and urinary bladder carcinoma: Collectively, these results are the first study indicating that MT2A modulated HO-1 expression (Figure 2 and Figure 4); moreover, CAPE induced MT2A and HO-1 to alleviate endogenous ROS and the activation of CAPE on HO-1 is dependent on MT2A in bladder carcinoma cells (Figure 5).