Results of in vitro Ki67 proliferation and Matrigel invasion assays showed that MT2A knockdown bladder carcinoma cells grew faster and increased cell invasion more than the mock-knockdown bladder carcinoma cells, while MT2A-overexpressed bladder carcinoma cells grew slower than the mock-transfected bladder carcinoma cells (Figure 6). The gene discussed is MKI67; the disease is urinary bladder carcinoma.