Moreover, hydrophilic hyaluronic acid (HA) conjugated with hydrophobic curcumin form amphiphilic HA-ADH-CUR conjugates, and then subsequently self-assembled in aqueous solution to form nanoparticles HA@CUR NPs, effectively accumulated at the tumor site through endocytosis and attained a superior therapeutic effect of tumor growth inhibition [148]. Here, AVP is linked to neoplasm.