In addition, similar effects of curcumin on inducing G2 phase cell accumulation was observed in head and neck cancer SCC-9 cells, which indicated that curcumin could induce G2/M cell cycle arrest through inhibiting phosphatidylinositol-3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of the rapamycin (mTOR) pathway [64]. The gene discussed is AKT1; the disease is head and neck cancer.