Moreover, curcumin decreased EMT of cervical cancer SiHa cells via pirin-dependent mechanism, enhanced the expression of E-cadherin and reduced the expression of N-cadherin, vimentin, slug and Zinc finger E-box binding homeobox 1 (Zeb1) through decreasing the levels of Pirin, which was further verified after Pirin knockdown [92]. The gene discussed is ZEB1; the disease is cervical carcinoma.