CASP3 and Familial prostate cancer: Another study pointed out that curcumin promoted prostate cancer PC-3 and DU145 cells apoptosis via enhancing the expression of miR-30a-5p and downregulating PCNA clamp associated factor (PCLAF) expression to increase the levels of Bcl-2 associated X protein (Bax) and Cleaved-cysteinyl aspartate specific proteinase 3 (Caspase-3), and to decrease the expression of Bcl-2 and Caspase-3 [73].