Reactome enrichment analysis for the up-regulated genes showed that these genes belong to the following top-ten pathways: Cellular responses to stress; Cellular responses to stimuli; Factors involved in megakaryocyte development and platelet production; Hemostasis; TRAF6-mediated IRF7 activation; DDX58/IFIH1-mediated induction of interferon-α/β; Unfolded Protein Response; Cytokine Signaling in Immune system; Innate Immune System; and Infectious disease (Figure 1B). Here, RIGI is linked to infectious disease.