Since the downregulation of the AMPK/PGC-1α/SIRT3 pathway evokes mitochondrial dysfunction and aggravates myocardial injury after MI, the activation of the AMPK/PGC-1α/SIRT3 pathway can be an effective strategy to protect against myocardial oxidative stress and apoptosis after MI. Here, PPARGC1A is linked to myocardial infarction.