Recent experimental studies have demonstrated that microglia are significantly activated in migraine models, which are manifested as changes in cell morphology, increased number, and enlarged cell body, etc. In addition, the amount of microglial activation markers (Iba-1), IL-1β, and TNF-α were apparently increased in migraine rodent models, as well as reduced facial mechanical pain threshold. The gene discussed is IL1B; the disease is migraine disorder.