In contrast, the prolonged behavioral challenge (4-week stress) imposed a passive coping behavioral strategy and cognitive impairment, decreased the number of GABAergic neurons, hyperactivity of VGluT1-positive neurons, and increased the ratio of p-GluN2B, as well as decreasing the expression of Reelin and syn-PSD-95 in the hippocampus. This evidence concerns the gene DLG4 and Cognitive impairment.