NR3C1 and Anorexia: Some studies indicate that moderate beneficial stress induces elevated cortisol levels, which lead to cravings for sweets, fatty food, and increased exploratory activity, while long-term variable stress (over 3 weeks), due to prolonged and repeated increases in cortisol, glucocorticoid receptors (GR), inflammatory cytokines, etc., evoked neuroendocrine response, resulting in decreased food intake or even anorexia, weight loss, and emotional disorders, such as prolonging immobility time and decreasing desire to explore.