CCL2 and obesity due to melanocortin 4 receptor deficiency: In obesity, adipose tissue produces cytokines such as interleukin (specifically IL1ß and IL6), interferon γ (IFNγ), Tumor Necrosis Factor α (TNFα), and Monocyte Chemoattractant Protein 1 (MCP1), which promote chronic inflammation [102,103,104,105,106,107].