Considering the non-negligible role of NLRP3/ASC/caspase-1 axis-mediated inflammation in Alzheimer’s disease, Alzheimer’s disease transgenic mice with selective suppression of NLRP3 inflammasome or caspase-1 expressions in the brain revealed significantly improvement cognitive functions [75]. Here, CASP1 is linked to early-onset autosomal dominant Alzheimer disease.