Additionally, fluctuations in serum levels of cytokines such as interleukin-1 (IL-1), IL-2, IL-4, IL-6, tumor necrosis factor (TNF)- alpha, soluble TNF receptor 1 and soluble IL-2 receptor [10,11], acute phase reactants such as high sensitivity C reactive protein (hsCRP) [12], as well as microglia activation [13] and alterations in tryptophan metabolism (via the kynurenine pathway) [14] were reported in patients with bipolar disorder. The gene discussed is TNF; the disease is bipolar disorder.