Further, the increased plasma levels of IL-1β and PGE2 detected in DNBS mice at day 7 after colitis induction (113.1 ± 32.71 pg/mL and 348.5 ± 45.22 pg/mL for IL-1β and PGE2, respectively; p < 0.0001 vs. vehicle for both comparisons; Figure 3E,F) were significantly and dose-dependently decreased by PGA (62.1 ± 15.09 pg/mL and 36.7 ± 13.12 pg/mL for IL-1β in the lower and higher dose group, respectively; 217.5 ± 61.07 pg/mL and 169.7 ± 37.12 pg/mL for PGE2 in the lower and higher dose group, respectively; p < 0.0001 vs. DNBS for all comparisons; Figure 3E,F). Here, IL1B is linked to colitis.