PPARA and amyloidosis: Surprisingly, PEA was able to reduce or prevent, in a dose-dependent manner, the Aβ induced behavioral deficits, while it failed to rescue memory impairment in peroxisome proliferator-activated receptor-α (PPAR-α) null mice, thus further highlighting the importance of PPAR-α modulation for neuroprotection and PEA efficacy against amyloid neuronal damage [73].