Recently, in a sample of behavioral variant of FTD (bvFTD), synaptic loss was measured in vivo with synaptic vesicle glycoprotein 2A (SV2A)-PET, a metabolic marker of synaptopathy, in the anterior parahippocampal gyrus of a sample of bvFTD patients [38]. Here, SV2A is linked to frontotemporal dementia.