However, in the 6-OHDA-induced PD rat model, only the m6A level in the striatum was decreased, with significantly upregulated ALKBH5 expression and no change in FTO expression, while the m6A level in the midbrain was not significantly changed with upregulated FTO expression, in line with the PD neuron model, indicating that FTO may be transmitted through axons and mediate the demethylation of m6A-modified RNA in the striatum. This evidence concerns the gene ALKBH5 and Parkinson disease.