AKT1 and neoplasm: In addition, YTHDC1 may reduce the stability of phosphatase and tensin homolog (PTEN, a tumor suppressor gene that inhibits the downstream PI3K/Akt oncogenic pathway) and downregulate its expression by binding to the 3′ UTR of PTEN mRNA, thereby promoting Akt phosphorylation and NF-κB release, as well as cell survival, to play neuroprotective roles [92].