Second, studies on RNA m6A modification in glial cell tumors are also abundant, mainly illustrating that the expression of m6A regulators is significantly upregulated in GBM, such as hnRNPC, ALKBH5, and IGF2BP, suggesting that abnormal m6A modifications occur when glial cells undergo unrestricted proliferation. Here, ALKBH5 is linked to malignant glioma.