At the same time, because excessive Mn accumulation in the striatum can induce increased muscle tone, tremors, and other symptoms similar to those of PD, the expression of FTO was downregulated by the upstream transcription factor Foxo3a, thus leading to a decreased demethylation of epinephrine-B2 mRNA and an increase in its m6A level. The gene discussed is FTO; the disease is Parkinson disease.