Promising clinical trials have been performed in patients with rheumatoid arthritis using Hsp40-derived dnaJP1 (a highly conserved 15 aa peptide), as well as full-length Hsps, such as immuno-globulin binding protein (BiP, belonging to the Hsp70 family) and Hsp10. The gene discussed is HSPA1A; the disease is rheumatoid arthritis.