There is growing evidence from preclinical studies confirming the contribution of either Hsp90 or Hsp70 to the development and therapy of autoimmune skin diseases, such as autoimmune bullous skin diseases, psoriasis, systemic lupus erythematosus, vitiligo, alopecia areata, or systemic sclerosis. The gene discussed is HSP90AA1; the disease is systemic lupus erythematosus.