There is growing evidence from preclinical studies confirming the contribution of either Hsp90 or Hsp70 to the development and therapy of autoimmune skin diseases, such as autoimmune bullous skin diseases, psoriasis, systemic lupus erythematosus, vitiligo, alopecia areata, or systemic sclerosis. Here, HSP90AB1 is linked to systemic lupus erythematosus.