MMP14 and neoplasm: Pathologically, upregulated MT1-MMP is correlated with poor clinical outcomes, and it is involved in the tumor initiation, invasion, and metastasis of many types of cancers such as melanoma, pancreatic cancer, advanced neuroblastoma, small cell, and non-small cell lung cancer, mesothelioma, tongue squamous cell carcinoma, head and neck carcinoma, bladder cancer, breast cancer, colorectal cancer, and ovarian cancer [6].