MMP14 and neoplasm: Membrane type 1 matrix metalloproteinase (MT1-MMP; MMP-14) is a zinc-dependent type I transmembrane endopeptidase with very important roles both in physiological (epithelial morphogenesis, skeletal development, and wound healing) and pathological (angiogenesis, arthritis, tumor growth, and metastasis, obesity, inflammation, and atherosclerosis) events.