For the discrimination form vascular dementia, the AUC reaches 0.92, for the discrimination from progressive supranuclear palsy and corticobasal degeneration the AUC reaches 0.88 and, for the discrimination from Parkinson disease or multiple system atrophy, the AUC may reach 0.82, indicating that the diagnostic value of plasma pT181-Tau may approach that of CSF pT181-Tau [11]. The gene discussed is MAPT; the disease is multiple system atrophy.