For this study, a cell model that was engineered in our previous publication is used to investigate the role of IFITMs—SiHa cells originating from squamous cell carcinoma of the cervix which express IFITM1 and IFITM3 at detectable endogenous levels with a higher expression upon IFNγ stimulation (Figure 1A). Here, IFITM1 is linked to squamous cell carcinoma.