Conversely, an increase of Arr1 and Arr2 transcription was observed in the Retinitis Pigmentosa model ninaEG69D/+ [70] that exhibits defective Rh1 maturation and low Rh1 levels but also excessive ER stress and age-dependent degeneration [71,72,73,74]. This evidence concerns the gene ARRB1 and retinitis pigmentosa.