PPARGC1A and metabolic dysfunction-associated steatotic liver disease: In addition, the activity imbalances of transcription factor steroid regulatory element binding protein-1c (SREBP-1c), peroxisome proliferator-activated receptor-α (PPARα), nuclear factor-kB (NF-kB), and peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α) are key regulators of mitochondrial biosynthesis and oxidative phosphorylation function in NAFLD [73,74,75,76,77,78,79,80].