The expression of SIRT2 is significantly decreased in obese mice with fatty liver and NAFLD; liver-specific knockout of SIRT2 aggravates hepatic fat accumulation, inflammation, and insulin resistance induced by HFD, while overexpression of liver SIRT2 improves insulin sensitivity, oxidative stress, and mitochondrial dysfunction in obese mice [19,126]. The gene discussed is SIRT2; the disease is fatty liver disease.