STAT3 and metabolic dysfunction-associated steatotic liver disease: Mechanically, SIRT1 can participate in the occurrence and development of NAFLD by affecting signal molecules such as PGC-1α and SREBP-1c, FoxO1/3, STAT3, and AMPK, and restore the function of mitochondria by regulating mitochondrial fat oxidation and reducing the production of ROS, thus controlling the progress of NAFLD.