The expression of SIRT2 is significantly decreased in obese mice with fatty liver and NAFLD; liver-specific knockout of SIRT2 aggravates hepatic fat accumulation, inflammation, and insulin resistance induced by HFD, while overexpression of liver SIRT2 improves insulin sensitivity, oxidative stress, and mitochondrial dysfunction in obese mice [19,126]. This evidence concerns the gene SIRT2 and Insulin resistance.