Perhaps of note, the human homologs of many of the yeast Hsp90-interactors are associated with various diseases, including bacterial infections (e.g., tetanus (SEC18/NSF), infant botulism (YKT6/YKT6), and diphtheria (RRT2/DPH7)), cancer (e.g., breast mucinous carcinoma (TRX2/TXN), primary bone cancer (SLT2/MAPK7), and endometrial cancer (PKH1/PDPK1)), and neurodegeneration (amyotrophic lateral sclerosis (VPS21/RAB5A, CDC48/VCP, VPS60/CHMP5), Parkinson’s disease (BET4/RABGGTA, VPS35/VPS35, RIC1/RIC1), and dementia (CDC48/VCP, VPS60/CHMP5)) [20]. Here, CHMP5 is linked to amyotrophic lateral sclerosis.