DNA damage increases with age and in multiple neurological and neurodegenerative disorders, such as Alzheimer’s disease, which is a disorder that is characterized by the accumulation of double strand breaks (DSB) in both neuronal and glial cells [51], as well as a diminution in the expression of UDG1, polb, and bOGG1 glycosylases in AD brains, compared with age-matched controls [52]. Here, POLB is linked to early-onset autosomal dominant Alzheimer disease.