TNF and COVID-19: It became evident early on that severe COVID-19 is a systemic hyperinflammatory disease derived from the so-called cytokine storm, a term describing a condition of uncontrolled systemic hyperinflammation triggered by the release of a big amount of pro-inflammatory cytokines, such as IL-1, IL-6, IL-18, IFN-γ, and TNF-α, among others [11].