Using an independent dataset (TCGA-COAD) The Cancer Genome Atlas (TCGA) Colon Adenomarcinoma (COAD) dataset [16] which annotates 571 CRC patient samples by RNA-sequencing, we did not observe a unique sub-population of CRC patients with elevated IGHG3 expression in their tumours (Figure 1). Here, IGHG3 is linked to neoplasm.