When CYB5R3 siRNA was injected intravenously into mice they showed a decrease in lung cancer burden [26], with cellular effects including signalling alterations associated with extravasation, transforming growth factor beta (TGFβ) and hypoxia-inducible factor 1-alpha (HIFα) pathways, and apoptosis [61]. The gene discussed is TGFB1; the disease is lung carcinoma.