SEPHS1 clusters with a breast cancer-specific gene module that contains ESR1, the estrogen receptor (ER), which is overexpressed in breast cancers and enables hormone-dependent growth, and several other genes that functionally interact with ESR1, including transcriptional regulators in ER-dependent breast cancers SPDEF, FOXA1, and GATA3 [8]. The gene discussed is SPDEF; the disease is breast cancer.