In another study, METTL14 decreased P2RX6 (ligand-gated ion channel receptors) expression activation-facilitated RCC cell migration and invasion by inhibiting ATP-induced Ca2+ influx to increase the ERK1/2 and MMP9 signaling pathway in SN12-PM6 and 786-O RCC cell lines compared to HK2 [87] (Figure 2J). The gene discussed is P2RX6; the disease is renal cell carcinoma.