In a chemically induced bladder cancer model of normal human uroepithelial SV-HUC-1 cells and prostate epithelial RWPE-1 cells, METTL3 can upregulate CUB domain-containing protein 1 (CDCP1) in bladder cancer tissues using both methylation-dependent and methylation-independent mechanisms of METTL3 [89]. The gene discussed is METTL3; the disease is urinary bladder cancer.