RYR1 and cardiomyopathy: Similarly, the gene variant COL5A1: c.2799+22C>T was correlated to the achievement of diagnostic criteria regarding the characterization of the ventricular walls; and 3 different polymorphisms located on the RYR1 gene (c.7835+5A>G; c.8693-10G>C; c.8068-29_8068-27del) were associated with cardiomyopathy with prevalent LV involvement.