Notch1 and Notch2 mRNAs were upregulated in GLCs/cumulus cells of PCOS patients compared with those of control participants in some reports [15,18], while other reports showed that Notch2, Notch3, and Hes1 mRNAs were downregulated [16,17,19]. This evidence concerns the gene NOTCH1 and polycystic ovary syndrome.