For example, the circZFR/miR-545-3p/CBLL1 axis, circZFR/miR-195-5p/KPNA4 axis, and circZFR/miR-4302/ZNF121axis promoted the growth, migration, invasion, EMT, and chem-resistance, arrested cell cycle and inhibited apoptosis in LC [16, 32, 33]. This evidence concerns the gene CBLL1 and laryngotracheoesophageal cleft.