TARDBP and amyotrophic lateral sclerosis: We utilized a polyclonal pan TDP-43 antibody to assess the subcellular localization of full-length TDP-43 in ALS and control spinal cord motor neurons, revealing a 6.5-fold reduction in the proportion of motor neurons possessing nuclear TDP-43 in all ALS subgroups compared with controls (range: 3.7-to-9.5-fold; Fig. 1a, c, Table 1).