Following exclusion of a likely benign TP53 variant (detailed below), three variants likely unrelated to ependymoma (incidental findings from the ACMG v2.0 [34]) and duplicate patients (detailed in Table 2), just 2.9% (5/173) of children with ependymoma are reported to harbor pathogenic germline variants in known cancer genes. The gene discussed is TP53; the disease is cancer.