Still, pathogenic germline NF2 variants are relatively rare in the overall pediatric ependymoma population and thus explain only a minority of cases: Among the 173 children with ependymoma included in the reviewed pan-childhood cancer germline sequencing studies [10–19], only two patients (1.2%) were reported to harbor pathogenic NF2 alterations [10, 16] (Table 2), for whom neither tumor location nor molecular subclass were described. Here, NF2 is linked to neoplasm.