FRAS1 was identified to be the gene most associated both with METTL3 and YTHDF1 in non-small cell lung cancer (NSCLC) as shown in Fig. 1A (RMETTL3 = 0.730, RYTHDF1 = 0.452, P < 0.001, Additional file 1: Table S1). The gene discussed is YTHDF1; the disease is non-small cell lung carcinoma.