Next, we found an interesting phenotype that the mRNA level of FRAS1 was significantly lower in 106 paired of NSCLC tumor tissues than that in the corresponding normal tissues (Fig. 1B) whereas the Kaplan–Meier plotter analysis indicated that high FRAS1 expression was associated with shorter overall survival of NSCLC patients (log rank P = 7e-04, https://kmplot.com/analysis/, Fig. 1C), suggesting that FRAS1 might be a risk prognosis biomarker in NSCLC. This evidence concerns the gene FRAS1 and neoplasm.