Module 1 had a score of 11.79, consisted of 30 nodes and 171 edges and was mainly enriched for genes involved in DNA-template transcription initiation, regulation of pri-miRNA transcription by RNA polymerase II, nuclear receptor activity, Huntington disease and RNA polymerase II-specific DNA-binding TF binding (Fig. 5d). The gene discussed is TF; the disease is juvenile Huntington disease.