IGFBP2 and lobular neoplasia: The level of plasma IGFBP2 in active LN patients (n = 23) was significantly higher than that of the HC group (n = 18) and inactive LN (n = 18) (P < 0.01), whereas there were no significant changes observed compared with the HC group in inactive LN patients, as shown in Fig. 1F. The level of IGFBP2 mRNA and protein expression in the PBMCs of active LN patients was higher than that in the HC group (P < 0.05) (Fig. 1F, G).