IGFBP2 and systemic lupus erythematosus: Signaling by the PI3K/Akt/mTOR pathway profoundly affects mRNA translation through phosphorylation of downstream targets such as 4E-BP and RPS6KB1 [17]; we further explored the level of phosphorylation of 4E-BP1 and RPS6KB1 in lymphocytes of mouse models of lupus with IGFBP2 blockade treatment.