IGFBP2 and lobular neoplasia: The results of IHC staining showed that obvious deposition of IGFBP2 was observed in the renal tubules of LN patients, especially in class IV and IV + V patients (P < 0.05), as shown in Fig. 3B. But it still remains unclear whether IGFBP2 deposition in the local renal tubule is involved in the damage of lupus renal tubular cells and aggravates renal interstitial inflammation.