IGFBP2 and lobular neoplasia: There was a significant positive correlation between the expression of IGFBP2 and the SLEDAI-2 K score after 3 months of treatment in active LN patients (r = 0.562; P < 0.01), and a significant positive correlation between the change in SLEDAI-2 K before and after treatment (r = 0.375; P < 0.05) (Fig. 2F), suggesting that plasma IGFBP2 could be used as an indicator of poor disease prognosis.