NPM1 and acute myeloid leukemia: Treatment of the NPM1-mutated AML cell lines OCI-AML3 with deguelin, a rotenoid isolated from several plant species [46, 47], and IMS-M2 with (-)-epigallocatechin-3-gallate (ECGT) [48], a major catechin found in green tea, were effective in reducing the NPM1 mutant but not the wild-type protein and in inducing apoptosis.