Immune evasion in NPM1-mutated AML is also contributed by VISTA (V-domain Ig suppressor of T-cell activation) and ULBP1 (NKG2 ligand) immunoregulatory circuitries that are both significantly upregulated in NPM1-mutated AML patients [126] (Fig. 4). The gene discussed is NPM1; the disease is acute myeloid leukemia.