Menin inhibitors was also combined with inhibitors of FLT3 (mutated in about 40% of NPM1-mutated AML [3]), demonstrating a synergistic effect that resulted in stronger cell growth inhibition, apoptosis and differentiation of AML blast cells [98] and induction of long-lasting CR in PDX mice models of NPM1-mutated/FLT3-ITD AML [99]. This evidence concerns the gene NPM1 and acute myeloid leukemia.