Histological subtype, grade, tumour size, tumour infiltrating lymphocytes (TILs) density, and lymph nodal status are important prognostic variables supplemented by four biomarkers: estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor-2 (HER2) and Ki67 which are largely unchanged in almost 20 years. This evidence concerns the gene ERBB2 and neoplasm.