The release of neuronal proteins in extracellular vesicles has been reported to show a potential use of their quantification as a biomarker for different pathologies like Alzheimer’s in the case of SNAP-2530 and Parkinson’s, for the presynaptic SNARE protein complex (i.e. STX-1a, SNAP-25 and VAMP-2)32. Here, STX1A is linked to Parkinson disease.