These results are in line with reported data showing that other brain pathologies stimulate up-regulation of proteins in PBMCs as for example happens for α-synuclein in Parkinson’s disease patients59 or the increase of mRNAs like IL-1 (Interleukin) beta, IL-8, and IL-17 mRNA in PBMC during brain ischemia60. The gene discussed is CXCL8; the disease is Parkinson disease.