S100A4 and neoplasm: Within the primary tumor cohort, the subgroup “MACC1 and S100A4 high” experienced the shortest MFS, while the subgroup “MACC1 and S100A4 low” showed the longest MFS (median follow up: 167.2 months; median MFS of 69 and 131 months, respectively; p < 0.0001; Fig. 2E).