In breast and prostate cancers, HHEX inhibits cell migration through direct transcriptional activation of the TGF-β repressor gene Endoglin. In addition, HHEX is considered to play a tumor-suppressive role by repressing Goosecoid (GSC) and ESM1 in several cancers8,9,12. Here, TGFB1 is linked to Familial prostate cancer.